Emanuela Tolosano Selected Research

Haptoglobins

4/2024	Targeting circulating labile heme as a defense strategy against malaria.
1/2022	Divergent roles of haptoglobin and hemopexin deficiency for disease progression of Shiga-toxin-induced hemolytic-uremic syndrome in mice.
1/2019	Temporal and age-dependent effects of haptoglobin deletion on intracerebral hemorrhage-induced brain damage and neurobehavioral outcomes.
1/2016	Age-Dependent Effects of Haptoglobin Deletion in Neurobehavioral and Anatomical Outcomes Following Traumatic Brain Injury.
7/2008	Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.
4/2005	Haptoglobin modifies the hemochromatosis phenotype in mice.
12/2002	Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.

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Emanuela Tolosano Research Topics

Disease

12	Neoplasms (Cancer) 02/2022 - 02/2017
12	Hemolysis 01/2022 - 12/2002
6	Inflammation (Inflammations) 01/2022 - 04/2002
5	Colorectal Neoplasms (Colorectal Cancer) 02/2022 - 02/2017
4	Fibrosis (Cirrhosis) 01/2023 - 12/2002
3	Iron Overload 01/2023 - 06/2014
3	Thalassemia 01/2023 - 03/2013
3	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 12/2002
3	Infections 01/2022 - 04/2011
3	Hypoxia (Hypoxemia) 01/2020 - 01/2013
3	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2018 - 10/2009
3	Sickle Cell Anemia (Hemoglobin S Disease) 01/2018 - 03/2013
3	Anemia 06/2014 - 01/2013
2	Malaria 04/2024 - 01/2013
2	Cardiotoxicity 12/2022 - 01/2017
2	Pain (Aches) 01/2021 - 12/2016
2	Carcinogenesis 01/2020 - 01/2019
2	Liver Diseases (Liver Disease) 01/2020 - 08/2010
2	Cerebral Hemorrhage 01/2019 - 02/2016
2	Stroke (Strokes) 01/2019 - 05/2009
2	Bacterial Infections (Bacterial Infection) 02/2017 - 01/2013
2	Sepsis (Septicemia) 02/2017 - 04/2011
2	Rupture 01/2013 - 12/2002
1	Acute Kidney Injury (Acute Renal Failure) 04/2024
1	beta-Thalassemia (Cooley's Anemia) 01/2023
1	Cardiomyopathies (Cardiomyopathy) 01/2023
1	Breast Neoplasms (Breast Cancer) 12/2022
1	Burns 12/2022
1	Corneal Injuries 12/2022
1	Cholestasis 01/2022
1	Hemolytic-Uremic Syndrome 01/2022
1	Disease Progression 01/2022
1	Thrombotic Microangiopathies 01/2022
1	Chronic Pain 01/2021
1	Friedreich Ataxia (Friedreich's Ataxia) 05/2020
1	sideroblastic spinocerebellar ataxia Anemia 05/2020
1	X-linked sideroblastic anemia 05/2020
1	Posterior column ataxia 05/2020
1	Ataxia (Dyssynergia) 05/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 05/2020
1	Spinocerebellar Degenerations (Marinesco Sjogren Syndrome) 05/2020
1	Prostatic Neoplasms (Prostate Cancer) 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2020
1	Hereditary Sensory and Autonomic Neuropathies (HSAN) 12/2019
1	Vascular Remodeling 06/2019
1	Gliosis 01/2019
1	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/2018
1	Posterior column ataxia with retinitis pigmentosa 10/2017
1	Body Remains 02/2017
1	Citrullinemia 01/2017
1	Hyperammonemia 01/2017
1	Perinatal Death 01/2017

Drug/Important Bio-Agent (IBA)

32	Heme (Haem)IBA 04/2024 - 07/2008
13	HemopexinIBA 04/2024 - 12/2002
12	IronIBA 01/2023 - 04/2005
8	Hemoglobins (Hemoglobin)IBA 04/2024 - 11/2005
8	Proteins (Proteins, Gene)FDA Link 01/2023 - 04/2002
7	HaptoglobinsIBA 04/2024 - 12/2002
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/2021 - 02/2017
2	HepcidinsIBA 01/2023 - 01/2013
2	Transferrin (beta 2 Transferrin)IBA 01/2023 - 05/2015
2	EnzymesIBA 02/2022 - 01/2019
2	Heme Oxygenase-1IBA 01/2022 - 07/2008
2	Ferritins (Ferritin)IBA 01/2022 - 10/2009
2	Adenosine Triphosphate (ATP)IBA 06/2019 - 04/2011
2	Oxygen (Dioxygen)IBA 01/2018 - 01/2014
2	PorphyrinsIBA 06/2014 - 01/2014
2	phenylhydrazine (phenylhydrazine hydrochloride)IBA 05/2014 - 07/2008
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 12/2013 - 04/2002
1	Doxorubicin (Adriamycin)FDA LinkGeneric 12/2022
1	AnthracyclinesIBA 12/2022
1	Heme-Binding ProteinsIBA 12/2022
1	Methylcellulose (BFL)IBA 12/2022
1	AlkaliesIBA 12/2022
1	Small Interfering RNA (siRNA)IBA 02/2022
1	Metformin (Glucophage)FDA LinkGeneric 02/2022
1	AcidsIBA 02/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	CollagenIBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 01/2022
1	Shiga Toxin (Shigella Toxin)IBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	AgarIBA 08/2021
1	CalciumIBA 06/2019
1	ProstaglandinsIBA 01/2019
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2019
1	Complement System Proteins (Complement)IBA 01/2018
1	CytokinesIBA 02/2017
1	Interleukin-22 (IL-22)IBA 02/2017
1	Therapeutic UsesIBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	CitrullineIBA 01/2017
1	AntioxidantsIBA 01/2017
1	Urea (Carbamide)FDA LinkGeneric 01/2017
1	Acetylcysteine (Siran)FDA LinkGeneric 01/2017
1	Tocopherols (Tocopherol)IBA 01/2017

Therapy/Procedure

4	Therapeutics 10/2021 - 08/2010
2	Ligation 01/2022 - 04/2011
1	Drug Therapy (Chemotherapy) 12/2022
1	Liver Transplantation 01/2020